metaPreg - Bupropion (Smoking cessation indication) during pregnancy

Bupropion (Smoking cessation indication) updated on 10-20-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
39 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	0.31 [0.06, 1.52]	78%	2 studies	446	304	not evaluable	ROB	-
Small for gestational age (weight)	0.91 [0.65, 1.27]	0%	2 studies	568	304	not evaluable	ROB	-
1 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
2 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal medical care	0.88 [0.60, 1.27]	0%	2 studies	361	259	not evaluable	ROB	-
2 non statistically significant endpoints reported in only one study