Timolol (Ocular route only) (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Pellegrino, 2018	Italy 2003 - 2015	Pregnant women referred to the Teratology Information Service for a counseling about the safety of performed therapies.	Pregnant women with glaucoma and treated with topical Timolol monotherapy during the first trimester.	unexposed, disease free Healthy pregnant women with normal singleton pregnancies without significant exposure to any medications considered unsafe.	27 / 187	Twenty-seven women used timolol as monotherapy, one drop (0,2 mg) one time daily and 48 as part of multidrug therapy in association with prostaglandins analogues or carbonic anhydrase inhibitors (dorzolamide, brinzolamide) one drop one time daily.

Study	Country Study period	Case	Control	Sample size	Rmk