metaPreg - Timolol (Ocular route only) (versus unexposed) during pregnancy

Timolol (Ocular route only) (versus unexposed) updated on 12-17-2024

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	0.71 [0.04, 13.34]	-	1 study	5	22	not evaluable	ROB	-
Major congenital malformations	0.71 [0.04, 13.34]	-	1 study	5	22	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	1.06 [0.23, 4.98]	-	1 study	17	22	not evaluable	ROB	-
Preterm (< 37 weeks)	1.04 [0.12, 8.82]	-	1 study	8	24	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	3.28 [1.29, 8.32]	-	1 study	91	24	not evaluable	ROB	6.02 [1.91; .]
Gestational diabetes	2.80 [0.69, 11.27]	-	1 study	11	27	not evaluable	ROB	-
Preeclampsia	1.40 [0.16, 12.46]	-	1 study	6	27	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal death (< 28 days of life)	7.04 [0.14, 362.25]	-	1 study		27	not evaluable	ROB	-
Neonatal medical care	8.24 [0.50, 136.65]	-	1 study	2	22	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.21 [0.57, 8.61]	-	1 study	13	27	not evaluable	ROB	-
Elective/induced termination of pregnancy	0.99 [0.05, 19.69]	-	1 study	3	27	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks) / Stillbirths	38.06 [1.77, 816.22]	-	1 study	2	27	not evaluable	ROB	75.62 [2.95; .]
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