Isradipine (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Darcie, 2004	Brazil 1994 - 1997	Singleton newborns of mothers with arterial hypertension (specific hypertensive disease of pregnancy (SHDP) or chronic arterial hypertension (CAH) and super-imposed SHDP).	Newborns of hypertensive mothers treated with isradipine (5 mg twice a day) for at least 2 weeks before the delivery.	unexposed, sick Newborns of hypertensive mothers whose hypertension was controlled with diet only (without antihypertensive medication), for a minimum period of 2 weeks.	39 / 14	Study considered as a prospective cohort because no precision indicating that a randomization was carried out.
Wide-Swensson, 1995	Denmark and Sweden Not specified.	Women with hypertension in pregnancy (diastolic blood pressure between >= 95 and <110 mm Hg), singleton pregnancy, gestational age > 25 weeks (<37) without other medication, and otherwise healthy.	Women with hypertension in pregnancy randomized to capsules of oral slow-release isradipine 5 mg twice daily.	unexposed, sick Women with hypertension in pregnancy randomized to capsules of placebo given twice daily.	54 / 57	Data related to Apgar scores not reported because the number of available data for the 2 groups not provided by authors.

Study	Country Study period	Case	Control	Sample size	Rmk