Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg

Study Reference
Berard (150 mg), 2019

Berard Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies. CMAJ 2019; 191:E179-E187

Inman (single 150mg dose), 1994

Inman Safety of fluconazole in the treatment of vaginal candidiasis. A prescription-event monitoring study, with special reference to the outcome of pregnancy. Eur J Clin Pharmacol 1994; 46:115-8

Jick (92% received the single 150-mg dose preparation), 1999

Jick Pregnancy outcomes after maternal exposure to fluconazole. Pharmacotherapy 1999; 19:221-2

Molgaard-Nielsen (150 mg), 2013

Molgaard-Nielsen Use of oral fluconazole during pregnancy and the risk of birth defects. N. Engl. J. Med. 2013; 369:830-9