Fluconazole (all routes except local only) - Cumulative dose > 150 mg

Study Reference
Berard (> 150 mg), 2019

Berard Associations between low- and high-dose oral fluconazole and pregnancy outcomes: 3 nested case-control studies. CMAJ 2019; 191:E179-E187

Inman (> 150mg), 1994

Inman Safety of fluconazole in the treatment of vaginal candidiasis. A prescription-event monitoring study, with special reference to the outcome of pregnancy. Eur J Clin Pharmacol 1994; 46:115-8

Molgaard-Nielsen (300 - 6000mg), 2013

Molgaard-Nielsen Use of oral fluconazole during pregnancy and the risk of birth defects. N. Engl. J. Med. 2013; 369:830-9

Molgaard-Nielsen (> 350-5600), 2016

Molgaard-Nielsen Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth. JAMA 2016; 315:58-67

Pasternak (>300 mg), 2018

Pasternak Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death. JAMA 2018; 319:2333-2335