Oxprenolol (versus unexposed) - Medication and Pregnancy KB

Oxprenolol (versus unexposed)

Exposed non-exposed, cohort studies

Study	Country Study period Study design	Data source	Exposure definition	Non-exposure definition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Fidler 1983	United Kingdom (UK) Not specified. prospective cohort	The Queen Charlotte's Maternity Hospital, London, England.	Hypertensive pregnant patients allocated at random to receive oxprenolol (80mg twice a day and increased until 640 mg a day if necessary).	unexposed, disease free Normotensive pregnant women with the nearest hospital reference number after that of the index patient, matched for parity and gestational age at delivery.	during pregnancy (anytime or not specified)	50 / 96	Considered as a prospective cohort rather than a randomized control because patients were randomly allocated to methyldopa or oxprenolol but the Normotensive control group not randomly selected.
Fidler 1983	United Kingdom (UK) Not specified. prospective cohort	The Queen Charlotte's Maternity Hospital, London, England.	The patients were allocated at random to receive either methyldopa or oxprenolol.		during pregnancy (anytime or not specified)	50 / 96

Case-control studies

Study	Country Study period Study design	Data source	Case	Control	Exposition	Exposition period	Sample size (exposed/unexposed) Or (case / control)	Remarks	Risk of bias
Medveczky 2004	Hungary 1980 - 1996 case control	The Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).	Newborn infants (including infant deaths and usual stillborn fetuses) with Neural tube defects with non-syndromic (i.e. isolated anencephaly, spina bifida aperta/cystica, encephalocele).	Newborn infants (including infant deaths and usual stillborn fetuses) without congenital abnormalities.	Exposure data collected from 3 sources: a post-paid structured questionnaire sent to the parents requesting drugs taken during pregnancy, according to gestational months; maternal prenatal care logbook (in which obstetricians must record all prescribed drugs); nurses visited non-responding families.	1st trimester	1202 / 38151	Study design completed with other studies published on the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).
Medveczky 2004	Hungary 1980 - 1996 case control		The Hungarian Congenital Abnormality Registry (HCAR), in which notification by physicians of cases with Congenital anomalies is mandatory (including infant deaths and usual stillborn fetuses). Controls were selected from the National Birth Registry of the Central Statistical Office.			1st trimester	1202 / 38151
Puho 2007	Hungary 1980–1996 case control	Hungarian Case-ControlSurveillance of Congenital Abnormalities	Cases with isolated cleft lip with or without cleft palate (CL/P) and posterior cleft palate (PCP).	Newborn infants without congenital abnormalities	Mothers were asked to send their prenatal maternity logbook and other medical records and they were mailed a questionnaire. Regional nurses were asked to visit and question the non-respondent.	1st trimester	1975 / 38151
Puho 2007	Hungary 1980–1996 case control		Notification by physicians to the Hungarian Congenital Abnormality Registry. Pathologists sent a copy of each autopsy report to the registry for stillborn fetuses or infant deaths and defect diagnosed in prenatal diagnostic centers with or without termination of pregnancy were included.			1st trimester	1975 / 38151

Risk of bias: : NA; : low; : moderate; : serious; : critical; : unclear;

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