Oxprenolol (versus unexposed)

Study	Type of data	Exposure measurement	Outcome assessment	Adjustment
Fidler, 1983	prospective cohort	The patients were allocated at random to receive either methyldopa or oxprenolol.	All out patients were seen every two weeks until 36 weeks' gestation and thereafter every week until delivery.	Matched for parity and gestational age at delivery. Exclusion of patients that were taking other hypertensive medication, had diabetes, expecting twins, had renal disease, and had congenital adrenal hyperplasia. No difference in smoking.
Medveczky, 2004	case control	Exposure data collected from 3 sources: a post-paid structured questionnaire sent to the parents requesting drugs taken during pregnancy, according to gestational months; maternal prenatal care logbook (in which obstetricians must record all prescribed drugs); nurses visited non-responding families.	The Hungarian Congenital Abnormality Registry (HCAR), in which notification by physicians of cases with Congenital anomalies is mandatory (including infant deaths and usual stillborn fetuses). Controls were selected from the National Birth Registry of the Central Statistical Office.	Controls matched according to sex, birth week, and district of parents' residence. Multivariable unconditional logistic regression model for maternal age, birth order, and employment status.
Puho, 2007	case control	Mothers were asked to send their prenatal maternity logbook and other medical records and they were mailed a questionnaire. Regional nurses were asked to visit and question the non-respondent.	Notification by physicians to the Hungarian Congenital Abnormality Registry. Pathologists sent a copy of each autopsy report to the registry for stillborn fetuses or infant deaths and defect diagnosed in prenatal diagnostic centers with or without termination of pregnancy were included.	Adjusted for maternal age and employment status, parity and acute maternal diseases in the 2nd and/or 3rd months of pregnancy. Controls were matched according to sex, week of birth in the year when the case was born, and district of parent’s residence.

master protocol