Oxprenolol (versus unexposed)

Study	Country Study period	Population source	Exposure definition	Non-exposure definition	Sample size	Rmk
Fidler, 1983	United Kingdom (UK) Not specified.	All the women booked for delivery at Queen Charlotte's Maternity Hospital who had diastolic blood pressure of at least 95mm Hg on two separate occasions at least 24 hours apart or greater than105mm Hg on one occasion.	Hypertensive pregnant patients allocated at random to receive oxprenolol (80mg twice a day and increased until 640 mg a day if necessary).	unexposed, disease free Normotensive pregnant women with the nearest hospital reference number after that of the index patient, matched for parity and gestational age at delivery.	50 / 96	Considered as a prospective cohort rather than a randomized control because patients were randomly allocated to methyldopa or oxprenolol but the Normotensive control group not randomly selected.

Study	Country Study period	Case	Control	Sample size	Rmk
Medveczky, 2004	Hungary 1980 - 1996	Newborn infants (including infant deaths and usual stillborn fetuses) with Neural tube defects with non-syndromic (i.e. isolated anencephaly, spina bifida aperta/cystica, encephalocele).	Newborn infants (including infant deaths and usual stillborn fetuses) without congenital abnormalities.	1202 / 38151	Study design completed with other studies published on the Hungarian Case-Control Surveillance of Congenital Abnormalities (HCCSCA).
Puho, 2007	Hungary 1980–1996	Cases with isolated cleft lip with or without cleft palate (CL/P) and posterior cleft palate (PCP).	Newborn infants without congenital abnormalities	1975 / 38151