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Verapamil (versus unexposed)
Overall results
Study description
Excluded studies
Table
Graphic
auto
during pregnancy (anytime or not specified)
1st trimester
2nd trimester
3rd trimester
2nd and/or 3rd trimester
throughout pregnancy
early pregnancy
days before delivery
late pregnancy
preconception-only
periconceptional
preconceptional for kinetic reason
at least 1st trimester
3 months (or more) before pregnancy or during pregnancy
1st and 2nd trimester
3 months or more before pregnancy or1st trimester
Whatever the period exposition
individual studies
Outcome
TE
95% CI
n cases
n exposed
k
Pub. bias
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)
Weber-Schoendorfer, 2008
1
2.51
[
1.01
; 6.28]
39
56
not evaluable
Limb defects
Weber-Schoendorfer, 2008
1
1.89
[
0.10
; 36.98]
3
55
not evaluable
Major congenital malformations
Weber-Schoendorfer, 2008
1
1.91
[
0.42
; 8.63]
16
55
not evaluable
Neural Tube Defects
Medveczky, 2004
1
2.11
[
0.12
; 37.05]
1,202
8
not evaluable
Growth parameters and prematurity
Preterm (< 37 weeks)
Weber-Schoendorfer, 2008
1
4.01
[
1.98
; 8.11]
59
55
not evaluable
Intrauterine deaths
Early intrauterine death (< 22 weeks)
Weber-Schoendorfer, 2008
1
0.90
[
0.32
; 2.57]
63
58
not evaluable
Elective/induced termination of pregnancy
Weber-Schoendorfer, 2008
1
1.78
[
0.61
; 5.24]
34
62
not evaluable
Late intrauterine deaths (> 22 weeks)
Weber-Schoendorfer, 2008
1
2.25
[
0.27
; 19.02]
7
58
not evaluable
0.0
50.0
1.0
