Interferon beta (IFN-β)

Table   Graphic  
  individual studies
OutcomeTE95% CIn casesn exposedkPub. bias All congenital malformations (majors, minors, majors and minors, or unspecified) Boskovic (control unexposed, sick), 2005 Colvin (IFN beta-1b only), 2010 Finkelsztejn (control unexposed, sick), 2011 Thiel (unexposed, sick), 2016 Portaccio, 2018 51.07[0.53; 2.14]5,026402serious Major congenital malformations Boskovic (control unexposed, sick), 2005 Colvin (IFN beta-1b only), 2010 Thiel (unexposed, sick), 2016 Portaccio, 2018 41.02[0.48; 2.15]5,019333not evaluable Congenital cataract 0----- Minor congenital malformations Portaccio, 2018 10.95[0.10; 8.60]576not evaluable Preterm (< 37 weeks) Boskovic (control unexposed, sick), 2005 Weber-Schoendorfer (control unexposed, sick), 2009 Giannini (control unexposed, sick), 2012 Fragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 Thiel (unexposed, sick), 2016 Nguyen (control unexposed, sick), 2019 71.12[0.63; 1.99]384703not evaluable Low birth weight (< 2500g) Fragoso b (control unexposed, sick), 2013 15.76[1.52; 21.84]1117not evaluable Small for gestational age (weight) Thiel (unexposed, sick), 2016 10.81[0.27; 2.42]-226not evaluable Caesarean Lu (control unexposed, sick), 2012 10.65[0.13; 3.29]688not evaluable Preeclampsia Fragoso b (control unexposed, sick), 2013 11.33[0.14; 12.67]517not evaluable Assisted deliveries (forceps, vacuum, ...) Lu (control unexposed, sick), 2012 12.45[0.63; 9.53]3612not evaluable Gestational diabete Fragoso a (control exposed to Glatiramer), 2013 Fragoso b (control exposed to Glatiramer), 2013 20.51[0.05; 5.02]256not evaluable Maternal consequences (as a whole) Fragoso b (control unexposed, sick), 2013 10.55[0.15; 2.07]2817not evaluable Maternal infections Fragoso b (control unexposed, sick), 2013 12.72[0.23; 31.79]317not evaluable Placenta previa Fragoso b (control unexposed, sick), 2013 11.77[0.07; 45.30]117not evaluable Jaundice Finkelsztejn (control unexposed, sick), 2011 Fragoso a (control unexposed, sick), 2013 Fragoso b (control unexposed, sick), 2013 31.46[0.53; 4.01]19125not evaluable Neonatal death Fragoso b (control exposed to Glatiramer), 2013 Thiel (unexposed, sick), 2016 21.37[0.14; 13.46]2268not evaluable Neonatal disorders (as a whole) Fragoso b (control unexposed, sick), 2013 15.53[1.72; 17.79]1717not evaluable Neonatal medical care Fragoso a (control exposed to Glatiramer), 2013 13.08[0.12; 78.03]139not evaluable Children infections Fragoso a (control unexposed, sick), 2013 13.27[0.94; 11.45]1139not evaluable Intrauterine deaths (as a whole) Boskovic (control unexposed, sick), 2005 Weber-Schoendorfer (control unexposed, sick), 2009 Fragoso b (control unexposed, sick), 2013 Nguyen (control unexposed, sick), 2019 41.16[0.61; 2.22]95401not evaluable Early intrauterine death (< 22 weeks) Boskovic (control unexposed, sick), 2005 Giannini (control unexposed, sick), 2012 Thiel (unexposed, sick), 2016 31.40[0.82; 2.38]77361not evaluable Elective termination of pregnancy Giannini (control unexposed, sick), 2012 Thiel (unexposed, sick), 2016 Nguyen (control unexposed, sick), 2019 32.57[0.28; 23.52]51641not evaluable Late intrauterine deaths (> 22 weeks) Boskovic (control unexposed, sick), 2005 Giannini (control unexposed, sick), 2012 Thiel (unexposed, sick), 2016 31.96[0.36; 10.54]5361not evaluable Ectopic pregnancy Giannini (control unexposed, sick), 2012 10.72[0.03; 15.16]288not evaluable0.0100.01.0