Interferon beta (IFN-β)

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
All congenital malformations (majors, minors, majors and minors, or unspecified)1.07 [0.53, 2.14]0%5 studies5,026402serious
Major congenital malformations1.02 [0.48, 2.15]0%4 studies5,019333not evaluable
Congenital cataract--0 study
1 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Preterm (< 37 weeks)1.12 [0.63, 1.99]64%7 studies384703not evaluable
Low birth weight (< 2500g)5.76 [1.52, 21.84]-1 study1117not evaluable
1 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Gestational diabete0.51 [0.05, 5.02]0%2 studies256not evaluable
6 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Jaundice1.46 [0.53, 4.01]0%3 studies19125not evaluable
Neonatal death1.37 [0.14, 13.46]0%2 studies2268not evaluable
Neonatal disorders (as a whole)5.53 [1.72, 17.79]-1 study1717not evaluable
1 non statistically significant endpoints reported in only one study

Long term consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
1 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Intrauterine deaths (as a whole)1.16 [0.61, 2.22]23%4 studies95401not evaluable
Early intrauterine death (< 22 weeks)1.40 [0.82, 2.38]0%3 studies77361not evaluable
Elective termination of pregnancy2.57 [0.28, 23.52]66%3 studies51641not evaluable
Late intrauterine deaths (> 22 weeks)1.96 [0.36, 10.54]0%3 studies5361not evaluable
1 non statistically significant endpoints reported in only one study