metaPreg - Sumatriptan during pregnancy

Sumatriptan

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.00 [0.87, 1.14]	0%	5 studies	57,007	4,840	not evaluable	ROB	-
Major congenital malformations	1.07 [0.39, 2.88]	25%	4 studies	122	2,583	not evaluable	ROB	-
Congenital heart defects	2.31 [0.84, 6.39]	-	1 study	873	62	not evaluable	ROB	-
Digestive system anomalies	0.69 [0.04, 11.18]	-	1 study	362	58	not evaluable	ROB	-
Genital anomalies	0.80 [0.05, 12.89]	-	1 study	314	58	not evaluable	ROB	-
Limb defects	1.36 [0.08, 22.06]	-	1 study	184	58	not evaluable	ROB	-
Minor congenital malformations	0.12 [0.01, 2.29]	-	1 study	4	67	not evaluable	ROB	-
Nervous system anomalies	1.20 [0.07, 19.50]	-	1 study	208	58	not evaluable	ROB	-
Oro-facial clefts	0.85 [0.05, 13.77]	-	1 study	294	58	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.60 [0.43, 5.97]	79%	3 studies	103	691	not evaluable	ROB	-
Low birth weight (< 2500g)	0.92 [0.64, 1.33]	0%	3 studies	80	1,267	not evaluable	ROB	-
Small for gestational age (weight)	0.88 [0.56, 1.40]	-	1 study	82	575	not evaluable	ROB	-
Very low birth weight (< 1500g)	0.73 [0.10, 5.40]	-	1 study		658	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	1.53 [0.74, 3.16]	-	1 study	38	80	not evaluable	ROB	-
Postpartum hemorrhage	0.49 [0.25, 0.96]	-	1 study	82	104	not evaluable	ROB	3.51 [.; 1.25]
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal medical care	0.39 [0.15, 1.01]	-	1 study	47	104	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.06 [0.68, 1.67]	26%	4 studies	735	4,196	not evaluable	ROB	-
Elective/induced termination of pregnancy	1.02 [0.50, 2.05]	0%	3 studies	162	4,198	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks)	0.91 [0.16, 5.06]	0%	3 studies	20	4,198	not evaluable	ROB	-
Ectopic pregnancy	1.21 [0.07, 19.73]	-	1 study	2	76	not evaluable	ROB	-
Perinatal death	1.23 [0.40, 3.80]	-	1 study		658	not evaluable	ROB	-
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