Ethosuximide (All indications) updated on 04-22-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)2.66 [1.01, 7.00]0%8 studies49,67664not evaluable ROB4.77 [1.12; .]
Major congenital malformations2.87 [1.05, 7.84]0%8 studies49,67064not evaluable ROB5.19 [1.29; .]
Congenital heart defects4.26 [0.38, 47.27]0%2 studies912not evaluable ROB-
Hypospadias4.12 [0.37, 45.30]0%2 studies912not evaluable ROB-
Microcephaly / Small head circumference for gestational age1.54 [0.09, 26.28]-1 study134,02311not evaluable ROB-
Neural Tube Defects18.80 [1.26, 279.89]0%2 studies212not evaluable ROB37.09 [1.84; .]
Digestive system anomalies7.99 [0.39, 163.81]-1 study312not evaluable ROB-
Eye defects5.33 [0.29, 97.49]-1 study72not evaluable ROB-
Limb defects11.21 [0.51, 246.80]-1 study212not evaluable ROB-
Minor congenital malformations2.20 [0.19, 25.52]-1 study64not evaluable ROB-
Oro-facial clefts18.71 [0.72, 484.16]-1 study112not evaluable ROB-
Polydactyly6.33 [0.09, 458.24]-1 study2not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low birth weight (< 2500g)20.14 [0.40, 1017.27]-1 study2491not evaluable ROB-
Preterm (< 37 weeks)12.81 [0.25, 646.50]-1 study3831not evaluable ROB-
Small for gestational age (weight)7.87 [0.16, 397.17]-1 study5941not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation--0 study-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)--0 study-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neuro-developmental disorders (as a whole)8.50 [0.44, 163.89]-1 study52not evaluable ROB-

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