Nifedipine (versus unexposed)

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.31 [0.39, 4.42]-1 study3651not evaluable ROB-
Limb defects2.04 [0.10, 39.95]-1 study351not evaluable ROB-
Major congenital malformations2.07 [0.46, 9.35]-1 study1651not evaluable ROB-
Oesophageal atresia with or without tracheo-oesophageal fistula3.27 [0.98, 10.93]-1 study2219not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)2.97 [0.54, 16.34]94%2 studies172180not evaluable ROB-
Low birth weight (< 2500g)1.09 [0.64, 1.87]-1 study77129not evaluable ROB-
Very low birth weight (< 1500g)1.20 [0.48, 2.99]-1 study20129not evaluable ROB-
Very preterm (28 to 32 weeks)1.60 [0.79, 3.25]-1 study33129not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean0.70 [0.42, 1.16]-1 study149128not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal death (< 28 days of life)0.98 [0.14, 7.04]-1 study4132not evaluable ROB-
Neonatal medical care1.80 [0.70, 4.61]-1 study19123not evaluable ROB-
Infant health status 6.49 [0.34, 122.60]-1 study494not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant death (> 28 days of life)0.23 [0.01, 5.65]-1 study194not evaluable ROB-
Child/Infant lenght abnormalities (> 1 year)0.38 [0.13, 1.09]-1 study1694not evaluable ROB-
Child/Infant weight abnormalities (> 1 year)1.28 [0.53, 3.10]-1 study2594not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)1.08 [0.10, 11.26]61%2 studies72197not evaluable ROB-
Late intrauterine deaths (> 22 weeks)3.40 [0.85, 13.63]34%2 studies14197not evaluable ROB-
Elective/induced termination of pregnancy4.38 [2.10, 9.14]-1 study4176not evaluable ROB8.22 [3.61; .]
Therapeutic terminations of pregnancy0.98 [0.06, 15.79]-1 study2132not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Language disorders/delay1.27 [0.41, 3.98]-1 study1494not evaluable ROB-
Psychomotor developmental disorders/delay0.92 [0.20, 4.25]-1 study794not evaluable ROB-

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