Pregabalin (Epilepsy) updated on 12-01-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)5.55 [0.89, 34.62]0%3 studies15513not evaluable ROB-
Major congenital malformations5.55 [0.89, 34.62]0%3 studies15513not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low birth weight (< 2500g)0.92 [0.44, 1.92]-1 study1,014120not evaluable ROB-
Small for gestational age (weight)1.01 [0.58, 1.76]-1 study2,431120not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Maternal consequences (as a whole)1.41 [0.66, 3.02]-1 study66389not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)1.11 [0.71, 1.73]-1 study34197not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
ASD (Autism spectrum disorder): Diagnosis0.88 [0.08, 9.24]28%2 studies50354not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis/Risk0.88 [0.08, 9.24]28%2 studies50354not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis2.35 [0.01, 624.13]92%2 studies92954not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk2.35 [0.01, 624.13]92%2 studies92954not evaluable ROB-
Cognitive developmental disorders/delay (> 6 years old)0.61 [0.04, 9.96]-1 study19445not evaluable ROB-
Neuro-developmental disorders (as a whole)3.08 [1.50, 6.33]-1 study12237not evaluable ROB5.61 [2.36; .]
Severe cognitive developmental delay (Mental retardation) (> 6 years old)0.61 [0.04, 9.96]-1 study19445not evaluable ROB-
Cognitive developmental disorders/delay (3-6 years old)17.70 [0.97, 322.22]-1 study139not evaluable ROB-
Severe cognitive developmental delay (Mental retardation) (3-6 years old)17.70 [0.97, 322.22]-1 study139not evaluable ROB-

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