metaPreg - Pregabalin (Epilepsy) during pregnancy

Pregabalin (Epilepsy) updated on 04-22-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	5.82 [0.54, 62.65]	2%	2 studies	115	8	not evaluable	ROB	-
Major congenital malformations	5.82 [0.54, 62.65]	2%	2 studies	115	8	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	0.92 [0.44, 1.92]	-	1 study	1,014	120	not evaluable	ROB	-
Small for gestational age (weight)	1.01 [0.58, 1.76]	-	1 study	2,431	120	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Maternal consequences (as a whole)	1.41 [0.66, 3.02]	-	1 study	663	89	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
ASD (Autism spectrum disorder): Diagnosis	0.88 [0.08, 9.24]	28%	2 studies	503	54	not evaluable	ROB	-
ASD (Autism spectrum disorder): Diagnosis/Risk	0.88 [0.08, 9.24]	28%	2 studies	503	54	not evaluable	ROB	-
ADHD (Attention deficit hyperactivity disorder): Diagnosis	2.35 [0.01, 624.13]	92%	2 studies	929	54	not evaluable	ROB	-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk	2.35 [0.01, 624.13]	92%	2 studies	929	54	not evaluable	ROB	-
Cognitive developmental disorders/delay (> 6 years old)	0.61 [0.04, 9.96]	-	1 study	194	45	not evaluable	ROB	-
Severe cognitive developmental delay (Mental retardation) (> 6 years old)	0.61 [0.04, 9.96]	-	1 study	194	45	not evaluable	ROB	-
Cognitive developmental disorders/delay (3-6 years old)	17.70 [0.97, 322.22]	-	1 study	13	9	not evaluable	ROB	-
Severe cognitive developmental delay (Mental retardation) (3-6 years old)	17.70 [0.97, 322.22]	-	1 study	13	9	not evaluable	ROB	-
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