metaPreg - Diazepam during pregnancy

Diazepam updated on 02-10-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
Congenital heart defects	1.15 [1.03, 1.29]	6%	7 studies	97,380	20,029	not evaluable	ROB	1.57 [1.21; .]
Cleft lip with or without cleft palate	1.58 [0.92, 2.71]	61%	6 studies	4,309	146	not evaluable	ROB	-
Cleft palate	0.96 [0.50, 1.83]	0%	6 studies	1,955	103	not evaluable	ROB	-
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.18 [0.99, 1.41]	75%	5 studies	209,456	20,008	not evaluable	ROB	-
Major congenital malformations	1.18 [0.99, 1.41]	75%	5 studies	209,456	20,008	not evaluable	ROB	-
Oro-facial clefts	1.65 [0.28, 9.92]	61%	3 studies	178	2,024	not evaluable	ROB	-
Ano-rectal atresia and stenosis	1.30 [0.18, 9.45]	56%	3 studies	1,081	34	not evaluable	ROB	-
Eye defects	0.87 [0.16, 4.71]	43%	2 studies	21	1,159	not evaluable	ROB	-
Neural Tube Defects	0.65 [0.20, 2.16]	52%	3 studies	2,162	35	not evaluable	ROB	-
Oesophageal atresia with or without tracheo-oesophageal fistula	1.67 [0.60, 4.63]	0%	3 studies	762	35	not evaluable	ROB	-
Atresia or stenosis of other parts of small intestine	1.09 [0.41, 2.90]	0%	2 studies	8	16	not evaluable	ROB	-
Diaphragmatic hernia	1.31 [0.35, 4.81]	0%	2 studies	877	36	not evaluable	ROB	-
Gastroschisis	0.77 [0.29, 2.04]	0%	2 studies	1,400	19	not evaluable	ROB	-
Hydrocephaly	1.37 [0.55, 3.39]	0%	2 studies	513	19	not evaluable	ROB	-
Limb reduction defects (LRD)	2.46 [0.86, 7.03]	40%	2 studies	42	16	not evaluable	ROB	-
Omphalocele	0.99 [0.19, 5.16]	0%	2 studies	451	35	not evaluable	ROB	-
Ventricular septal defect	0.81 [0.24, 2.79]	0%	2 studies	1,798	29	not evaluable	ROB	-
Microcephaly / Small head circumference for gestational age	-	-	0 study					-
26 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.13 [1.07, 1.20]	-	1 study	228,891	13,534	not evaluable	ROB	1.51 [1.33; .]
Small for gestational age (weight)	1.25 [1.18, 1.33]	-	1 study	272,109	11,021	not evaluable	ROB	1.81 [1.63; .]
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.11 [1.11, 4.02]	56%	2 studies	27,149	27	not evaluable	ROB	3.64 [1.46; .]
Late intrauterine deaths (> 22 weeks) / Stillbirths	1.46 [1.26, 1.69]	-	1 study	26,603	13,726	not evaluable	ROB	2.28 [1.83; .]