Leflunomide

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
All congenital malformations (majors, minors, majors and minors, or unspecified)0.97 [0.81, 1.16]0%3 studies14,378116not evaluable
Major congenital malformations0.97 [0.81, 1.16]0%3 studies14,378116not evaluable
3 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
preterm (< 37 weeks)1.94 [1.03, 3.67]0%3 studies10,87180not evaluable
low birth weight (< 2500g)1.06 [0.90, 1.25]0%2 studies23not evaluable
3 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Caesarean--0 study
2 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Infant weight abnormalities25.59 [1.44, 453.91]-1 study856not evaluable

Intrauterine deaths
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Early intrauterine death (< 22 weeks)1.09 [0.90, 1.32]0%2 studies17,747112not evaluable
3 non statistically significant endpoints reported in only one study