metaPreg - Leflunomide during pregnancy

Leflunomide

Table Graphic exposition period:

Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	???
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)		0.97 [0.81, 1.16]	0%	3 studies	14,378	116	not evaluable
Major congenital malformations		0.97 [0.81, 1.16]	0%	3 studies	14,378	116	not evaluable
3 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	???
Preterm (< 37 weeks)		1.94 [1.03, 3.67]	0%	3 studies	10,871	80	not evaluable
Low birth weight (< 2500g)		1.06 [0.90, 1.25]	0%	2 studies	2	3	not evaluable
3 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	???
Caesarean		-	-	0 study
2 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	???
Infant weight abnormalities		25.59 [1.44, 453.91]	-	1 study	8	56	not evaluable
Intrauterine deaths
Adverse outcome	Verdict	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	???
Early intrauterine death (< 22 weeks)		1.09 [0.90, 1.32]	0%	2 studies	17,747	112	not evaluable
3 non statistically significant endpoints reported in only one study