metaPreg - Propranolol (versus unexposed) during pregnancy

Propranolol (versus unexposed) updated on 12-17-2024

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
Hypospadias	1.60 [0.24, 10.83]	65%	2 studies	10,284	7	not evaluable	ROB	-
8 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Small for gestational age (weight)	2.63 [1.25, 5.52]	81%	4 studies	46,396	801	not evaluable	ROB	4.70 [1.81; .]
Low birth weight (< 2500g)	1.53 [1.11, 2.11]	0%	2 studies	19,451	515	not evaluable	ROB	2.44 [1.47; .]
1 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	1.30 [1.07, 1.56]	-	1 study	104,366	489	not evaluable	ROB	1.92 [1.36; .]
2 non statistically significant endpoints reported in only one study
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low Apgar score (< 7) (at 1 min)	1.60 [1.13, 2.26]	-	1 study	16,789	489	not evaluable	ROB	2.57 [1.50; .]
Low Apgar score (< 7) (at 10 min)	3.24 [1.45, 7.26]	-	1 study	1,436	489	not evaluable	ROB	5.93 [2.25; .]
2 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Late intrauterine deaths (> 22 weeks)	14.00 [1.86, 105.27]	-	1 study	10	9	not evaluable	ROB	27.49 [3.13; .]
Perinatal death	7.00 [1.04, 46.95]	-	1 study	12	9	not evaluable	ROB	13.48 [1.26; .]