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Preg
- medecines during pregnancy KB
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Hydroxychloroquine (for bibliographic search)
Summary
Overall results
Study description
Excluded studies
Umbrella review
Table
Graph
Published MA
OR
95% CI
n
k
I2
ROB
All congenital malformations (majors, minors, majors and minors, or unspecified)
metaPreg
1.26
[1.08; 1.48]
18
0%
0
-
Sperber (Autoimmune diseases), 2009
versus whatever (meta-analysis)
0.66
[0.25; 1.75]
4
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.53
[0.14; 2.04]
4
0%
0
-
Major congenital malformations
metaPreg
1.26
[1.06; 1.50]
12
2%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.13
[0.59; 2.17]
6
16%
0
-
Nervous system anomalies
metaPreg
2.66
[0.11; 65.66]
1
-
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.81
[0.31; 10.52]
3
0%
0
-
Congenital heart defects
metaPreg
1.37
[0.75; 2.49]
3
0%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.06
[0.29; 3.86]
4
0%
0
-
Intrauterine deaths (as a whole or unspecified)
metaPreg
0.62
[0.39; 1.00]
13
64%
0
-
Clowse (All SLE (lupus) pregnancies), 2022
versus whatever (meta-analysis)
0.83
[0.63; 1.09]
7
-
0
-
Clowse (Antiphospholipid syndrome), 2022
versus whatever (meta-analysis)
Out of scale
0.46
[0.10; 2.06]
-
-
0
-
Early intrauterine death (< 22 weeks)
metaPreg
0.97
[0.62; 1.52]
16
59%
0
-
Sperber (Autoimmune diseases), 2009
versus whatever (meta-analysis)
0.92
[0.49; 1.72]
4
0%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.85
[1.10; 3.13]
4
13%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.77
[1.09; 2.88]
4
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
1.77
[0.96; 3.26]
5
35%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.58
[0.24; 1.39]
2
0%
0
-
Late intrauterine deaths (> 22 weeks)
metaPreg
0.78
[0.46; 1.33]
14
0%
0
-
Sperber (Autoimmune diseases), 2009
versus whatever (meta-analysis)
0.94
[0.14; 6.54]
4
72%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
0.69
[0.35; 1.34]
6
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
1.00
[0.50; 2.00]
6
0%
0
-
Preterm (< 37 weeks)
metaPreg
0.91
[0.70; 1.18]
27
64%
0
-
Sperber (Autoimmune diseases), 2009
versus whatever (meta-analysis)
1.08
[0.74; 1.57]
4
0%
0
-
Guillotin (SLE indication), 2018
versus whatever (meta-analysis)
0.54
[0.26; 1.15]
6
54%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
1.75
[0.95; 3.24]
5
72%
0
-
Clowse (All SLE (lupus) pregnancies), 2022
versus whatever (meta-analysis)
0.68
[0.39; 1.18]
7
-
0
-
Clowse (Antiphospholipid syndrome), 2022
versus whatever (meta-analysis)
0.88
[0.09; 8.97]
-
-
0
-
Naveau (SLE indication), 2020
versus whatever (meta-analysis)
0.61
[0.40; 0.93]
-
47%
0
-
Tian (Antiphospholipid antibody syndrome), 2021
versus whatever (meta-analysis)
Out of scale
0.43
[0.13; 1.37]
2
50%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.55
[0.36; 0.86]
8
41%
0
-
Low birth weight (< 2500g)
metaPreg
0.78
[0.45; 1.34]
6
56%
0
-
Guillotin (SLE indication), 2018
versus whatever (meta-analysis)
0.62
[0.24; 1.64]
5
66%
0
-
Kaplan (All indications), 2016
versus whatever (meta-analysis)
0.69
[0.21; 2.27]
2
72%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.77
[0.43; 1.39]
5
38%
0
-
Small for gestational age (weight)
metaPreg
0.84
[0.63; 1.11]
22
41%
0
-
Tian (Antiphospholipid antibody syndrome), 2021
versus whatever (meta-analysis)
Out of scale
0.22
[0.13; 1.88]
2
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.57
[0.06; 5.43]
3
88%
0
-
Gestational diabetes
metaPreg
0.87
[0.76; 0.99]
4
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
2.30
[0.44; 12.12]
2
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.88
[0.19; 3.96]
2
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
Out of scale
0.26
[0.05; 1.51]
2
7%
0
-
Preeclampsia
metaPreg
Out of scale
0.44
[0.29; 0.68]
20
42%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
Out of scale
0.35
[0.21; 0.59]
6
22%
0
-
Clowse (All SLE (lupus) pregnancies), 2022
versus whatever (meta-analysis)
0.89
[0.62; 1.29]
7
-
0
-
Clowse (Antiphospholipid syndrome), 2022
versus whatever (meta-analysis)
0.60
[0.28; 1.28]
-
-
0
-
Naveau (SLE indication), 2020
versus whatever (meta-analysis)
Out of scale
0.49
[0.59; 1.01]
-
49%
0
-
Liu (SLE indication), 2021
versus unexposed, sick
0.61
[0.34; 1.11]
3
11%
0
-
Fetal distress
metaPreg
0.63
[0.33; 1.19]
3
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
1.07
[0.41; 2.76]
5
0%
0
-
Low Apgar score (< 7) (at 5 min)
metaPreg
Out of scale
0.41
[0.23; 0.72]
4
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.72
[0.20; 2.58]
2
0%
0
-
Oligohydramnios
metaPreg
0.54
[0.15; 1.96]
2
0%
0
-
Duan (SLE indication), 2021
versus unexposed, sick
0.90
[0.38; 2.14]
3
40%
0
-
0.5
5.0
1.0