Gabapentin (Epilepsy) updated on 04-22-2025

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.31 [0.41, 4.22]0%5 studies13385not evaluable ROB-
Major congenital malformations1.44 [0.45, 4.66]0%5 studies12885serious ROB-
Atrial septal defect--0 study-
8 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)10.63 [0.54, 209.24]0%2 studies43not evaluable ROB-
2 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Withdrawal syndrome / Neonatal abstinence syndrome / Poor neonatal adaptation--0 study-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)4.41 [0.49, 39.98]0%3 studies317not evaluable ROB-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions4.64 [0.23, 93.20]0%2 studies23not evaluable ROB-
3 non statistically significant endpoints reported in only one study

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk1.32 [0.68, 2.55]0%3 studies97275not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis1.71 [0.74, 3.98]0%2 studies97261not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis1.30 [0.30, 5.66]0%3 studies62not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis/Risk1.30 [0.30, 5.66]0%3 studies62not evaluable ROB-
Cognitive developmental disorders/delay (3-6 years old)2.30 [0.18, 29.32]38%2 studies20761not evaluable ROB-
Severe cognitive developmental delay (Mental retardation) (3-6 years old)2.30 [0.18, 29.32]38%2 studies20761not evaluable ROB-
Neuro-developmental disorders (as a whole)7.99 [0.44, 143.69]0%2 studies62not evaluable ROB-
4 non statistically significant endpoints reported in only one study

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