metaPreg - Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg during pregnancy

Fluconazole (all routes except local only) - Cumulative dose ≤ 150 mg updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.03 [0.89, 1.19]	0%	3 studies	44,784	5,229	not evaluable	ROB	-
Limb defects	0.84 [0.54, 1.30]	31%	3 studies	12,443	5,229	not evaluable	ROB	-
Congenital heart defects	1.29 [0.96, 1.74]	0%	2 studies	7,885	4,316	not evaluable	ROB	-
Major congenital malformations	1.03 [0.89, 1.19]	0%	3 studies	44,784	5,229	not evaluable	ROB	-
Cleft lip with or without cleft palate	0.91 [0.38, 2.18]	-	1 study	1,269	4,082	not evaluable	ROB	-
Cleft palate	0.90 [0.22, 3.65]	-	1 study	499	4,082	not evaluable	ROB	-
Eye defects	1.03 [0.33, 3.23]	-	1 study	728	913	not evaluable	ROB	-
Genital anomalies	1.70 [0.84, 3.44]	-	1 study	1,179	913	not evaluable	ROB	-
Nervous system anomalies	1.18 [0.49, 2.85]	-	1 study	899	913	not evaluable	ROB	-
Oro-facial clefts	2.32 [0.09, 57.20]	-	1 study	1	234	not evaluable	ROB	-
Polydactyly	0.71 [0.16, 3.07]	0%	2 studies	599	4,316	not evaluable	ROB	-
Tetralogy of Fallot	3.18 [1.18, 8.56]	-	1 study	291	4,082	not evaluable	ROB	5.81 [1.64; .]
Urinary malformations	1.31 [0.73, 2.34]	-	1 study	2,203	913	not evaluable	ROB	-
Ventricular septal defect	1.02 [0.60, 1.73]	-	1 study	3,186	4,082	not evaluable	ROB	-
Cardiac septal defects	0.98 [0.58, 1.64]	-	1 study	3,282	913	not evaluable	ROB	-
Craniosynostosis	0.34 [0.05, 2.38]	-	1 study	717	4,082	not evaluable	ROB	-
Diaphragmatic hernia	2.41 [0.60, 9.71]	-	1 study	204	4,082	not evaluable	ROB	-
Digestive system anomalies	0.66 [0.16, 2.70]	-	1 study	625	913	not evaluable	ROB	-
Hypoplastic left heart (HLH/HLHS)	2.28 [0.57, 9.17]	-	1 study	186	4,082	not evaluable	ROB	-
Limb reduction defects (LRD)	1.26 [0.40, 3.94]	-	1 study	556	4,082	not evaluable	ROB	-
Spina bifida	3.49 [0.32, 38.66]	-	1 study	3	234	not evaluable	ROB	-
Syndactyly	0.35 [0.05, 2.48]	-	1 study	680	4,082	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.09 [0.23, 5.14]	90%	2 studies	29,496	1,759	not evaluable	ROB	-
Ectopic pregnancy	-	-	0 study					-
Late intrauterine deaths (> 22 weeks) / Stillbirths	0.56 [0.13, 2.41]	-	1 study	712	31	not evaluable	ROB	-
Therapeutic terminations of pregnancy	1.43 [0.66, 3.10]	-	1 study	38	58	not evaluable	ROB	-
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