metaPreg - Esomeprazole during pregnancy

Esomeprazole updated on 01-14-2026

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.10 [1.02, 1.19]	0%	3 studies	108,511	14,288	not evaluable	ROB	1.44 [1.16; .]
Major congenital malformations	1.10 [1.02, 1.19]	0%	3 studies	108,511	14,288	not evaluable	ROB	1.44 [1.16; .]
Cleft palate	0.97 [0.53, 1.78]	-	1 study	2,292	12,516	not evaluable	ROB	-
Congenital heart defects	1.09 [0.97, 1.23]	-	1 study	42,434	12,516	not evaluable	ROB	-
Hydrocephaly	0.43 [0.11, 1.71]	-	1 study	786	12,516	not evaluable	ROB	-
Hypospadias	0.64 [0.30, 1.37]	-	1 study	1,806	6,476	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	0.93 [0.86, 1.01]	-	1 study	104,782	12,868	not evaluable	ROB	-
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