Propranolol (versus unexposed) updated on 12-17-2024

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Hypospadias1.60 [0.24, 10.83]65%2 studies10,2847not evaluable ROB-
All congenital malformations (majors, minors, majors and minors, or unspecified)0.75 [0.37, 1.53]-1 study4,062442not evaluable ROB-
Atrial septal defect0.60 [0.13, 2.88]-1 study7,01231not evaluable ROB-
Cleft lip with or without cleft palate1.40 [0.40, 4.90]-1 study3,62432not evaluable ROB-
Cleft palate2.60 [0.78, 8.67]-1 study2,00132not evaluable ROB-
Club foot / Talipes equinovarus1.80 [0.62, 5.25]-1 study4,413not evaluable ROB-
Congenital heart defects0.70 [0.34, 1.46]-1 study32,44441not evaluable ROB-
Major congenital malformations0.75 [0.37, 1.53]-1 study4,062442not evaluable ROB-
Neural Tube Defects0.45 [0.06, 3.29]-1 study3,88930not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Small for gestational age (weight)2.63 [1.25, 5.52]81%4 studies46,396801not evaluable ROB4.70 [1.81; .]
Low birth weight (< 2500g)1.53 [1.11, 2.11]0%2 studies19,451515not evaluable ROB2.44 [1.47; .]
Very low birth weight (< 1500g)1.79 [0.89, 3.61]-1 study3,449489not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Assisted deliveries (forceps, vacuum, ...)0.74 [0.37, 1.49]-1 study8,241489not evaluable ROB-
Caesarean1.30 [1.07, 1.56]-1 study104,366489not evaluable ROB1.92 [1.36; .]
Preeclampsia0.99 [0.32, 3.07]-1 study2,333489not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)1.60 [1.13, 2.26]-1 study16,789489not evaluable ROB2.57 [1.50; .]
Low Apgar score (< 7) (at 10 min)3.24 [1.45, 7.26]-1 study1,436489not evaluable ROB5.93 [2.25; .]
Low Apgar score (< 7) (at 5 min)1.78 [0.84, 3.76]-1 study3,031489not evaluable ROB-
Neonatal death (< 28 days of life)0.29 [0.01, 6.93]-1 study29not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Late intrauterine deaths (> 22 weeks)14.00 [1.86, 105.27]-1 study109not evaluable ROB27.49 [3.13; .]
Perinatal death7.00 [1.04, 46.95]-1 study129not evaluable ROB13.48 [1.26; .]

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