Triptans

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
All congenital malformations (majors, minors, majors and minors, or unspecified)0.99 [0.85, 1.15]0%4 studies57,1464,397not evaluable
Major congenital malformations0.97 [0.81, 1.17]0%4 studies39,0574,392not evaluable
Congenital heart defects1.32 [0.61, 2.88]57%2 studies13,7072,839not evaluable
Minor congenital malformations0.68 [0.06, 8.05]66%2 studies46387not evaluable
Eye defects--0 study
Urinary malformations--0 study
Abdominal wall defects--0 study
Ear, face and neck anomalies--0 study
Other anomalies/syndromes (non chromosomal)--0 study
9 non statistically significant endpoints reported in only one study

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
preterm (< 37 weeks)1.03 [0.71, 1.48]73%7 studies4,4702,480not evaluable
low birth weight (< 2500g)0.92 [0.71, 1.19]0%5 studies3,5782,692not evaluable
small for gestational age (weight)1.08 [0.85, 1.38]0%2 studies2991,861not evaluable
1 non statistically significant endpoints reported in only one study

Maternal consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Preeclampsia--0 study
4 non statistically significant endpoints reported in only one study

Neonatal disorders
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
2 non statistically significant endpoints reported in only one study

Intrauterine deaths
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Early intrauterine death (< 22 weeks)1.64 [0.94, 2.86]66%4 studies5,012686not evaluable
Elective termination of pregnancy1.11 [0.42, 2.98]15%2 studies108508not evaluable
Late intrauterine deaths (> 22 weeks)0.65 [0.11, 3.86]0%2 studies7508not evaluable
3 non statistically significant endpoints reported in only one study