metaPreg - Fluconazole (all routes except local only) - Cumulative dose > 150 mg during pregnancy

Fluconazole (all routes except local only) - Cumulative dose > 150 mg updated on 01-29-2025

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.20 [0.99, 1.46]	0%	2 studies	44,750	3,670	not evaluable	ROB	-
Limb defects	1.18 [0.80, 1.75]	0%	2 studies	12,441	3,670	not evaluable	ROB	-
Cleft lip with or without cleft palate	1.26 [0.42, 3.77]	-	1 study	1,269	3,270	not evaluable	ROB	-
Cleft palate	1.69 [0.39, 7.30]	-	1 study	500	3,270	not evaluable	ROB	-
Congenital heart defects	1.06 [0.67, 1.68]	-	1 study	7,867	3,270	not evaluable	ROB	-
Eye defects	1.50 [0.37, 6.11]	-	1 study	728	400	not evaluable	ROB	-
Genital anomalies	2.30 [0.94, 5.62]	-	1 study	1,179	400	not evaluable	ROB	-
Major congenital malformations	1.20 [0.99, 1.46]	0%	2 studies	44,750	3,670	not evaluable	ROB	-
Nervous system anomalies	1.97 [0.72, 5.39]	-	1 study	899	400	not evaluable	ROB	-
Tetralogy of Fallot	3.20 [0.74, 13.82]	-	1 study	290	3,270	not evaluable	ROB	-
Urinary malformations	1.41 [0.62, 3.22]	-	1 study	2,203	400	not evaluable	ROB	-
Ventricular septal defect	1.55 [0.84, 2.86]	-	1 study	3,189	3,270	not evaluable	ROB	-
Cardiac septal defects	1.81 [1.04, 3.15]	-	1 study	3,282	400	not evaluable	ROB	3.02 [1.25; .]
Craniosynostosis	1.94 [0.65, 5.80]	-	1 study	721	3,270	not evaluable	ROB	-
Digestive system anomalies	1.95 [0.60, 6.33]	-	1 study	625	400	not evaluable	ROB	-
Hypoplastic left heart (HLH/HLHS)	2.33 [0.33, 16.58]	-	1 study		2,252	not evaluable	ROB	-
Polydactyly	2.71 [1.01, 7.27]	-	1 study		2,252	not evaluable	ROB	4.86 [1.11; .]
Syndactyly	0.62 [0.09, 4.34]	-	1 study		2,252	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal death (< 28 days of life)	0.66 [0.27, 1.61]	-	1 study	182	4,530	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	2.42 [1.28, 4.56]	73%	3 studies	30,070	1,238	not evaluable	ROB	4.27 [1.88; .]
Late intrauterine deaths (> 22 weeks) / Stillbirths	1.31 [0.32, 5.34]	85%	3 studies	1,195	5,153	not evaluable	ROB	-
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