Metoprolol (versus unexposed) updated on 12-17-2024

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)3.71 [1.33, 10.34]-1 study4,05847not evaluable ROB6.88 [2.00; .]
Cleft palate2.10 [0.79, 5.61]-1 study601124not evaluable ROB-
Hypospadias1.82 [0.33, 10.05]-1 study2,1316not evaluable ROB-
Major congenital malformations3.71 [1.33, 10.34]-1 study4,05847not evaluable ROB6.88 [2.00; .]

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Small for gestational age (weight)1.74 [0.96, 3.14]6%3 studies32,530352not evaluable ROB-
Low birth weight (< 2500g)2.57 [2.35, 2.80]0%2 studies19,436870not evaluable ROB4.57 [4.14; .]
Preterm (< 37 weeks)2.07 [1.88, 2.27]-1 study490not evaluable ROB3.56 [3.17; .]
Very low birth weight (< 1500g)3.43 [1.83, 6.45]-1 study3,451324not evaluable ROB6.32 [3.06; .]

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean2.26 [1.77, 2.89]79%2 studies104,3421,975not evaluable ROB3.95 [2.94; .]
Assisted deliveries (forceps, vacuum, ...)1.27 [0.65, 2.47]-1 study8,242324not evaluable ROB-
Preeclampsia2.00 [0.74, 5.36]-1 study2,334324not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)1.33 [0.84, 2.11]-1 study16,774324not evaluable ROB-
Low Apgar score (< 7) (at 10 min)2.44 [0.78, 7.61]-1 study1,433324not evaluable ROB-
Low Apgar score (< 7) (at 5 min)3.11 [1.54, 6.28]-1 study3,032324not evaluable ROB5.67 [2.45; .]
Low Apgar score (< 7) (NOS)1.59 [1.46, 1.74]-1 study593not evaluable ROB2.56 [2.27; .]
Neonatal bradycardia0.59 [0.32, 1.09]-1 study731,484not evaluable ROB-
Neonatal hypoglycemia1.64 [1.15, 2.33]-1 study1401,484not evaluable ROB2.66 [1.57; .]

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