metaPreg - Beta-blockers (Ocular route only) (versus unexposed) during pregnancy

Beta-blockers (Ocular route only) (versus unexposed) updated on 12-17-2024

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.20 [0.36, 4.01]	0%	2 studies	55	53	not evaluable	ROB	-
Major congenital malformations	1.20 [0.36, 4.01]	0%	2 studies	55	53	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	1.36 [0.83, 2.21]	0%	4 studies	203	286	not evaluable	ROB	-
Preterm (< 37 weeks)	0.69 [0.20, 2.36]	0%	3 studies	47	103	not evaluable	ROB	-
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Caesarean	2.90 [1.29, 6.50]	0%	2 studies	103	72	not evaluable	ROB	5.24 [1.90; .]
Gestational diabetes	2.80 [0.69, 11.27]	-	1 study	11	27	not evaluable	ROB	-
Preeclampsia	1.40 [0.16, 12.46]	-	1 study	6	27	not evaluable	ROB	-
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal medical care	2.02 [0.24, 17.03]	44%	2 studies	9	70	not evaluable	ROB	-
Neonatal death (< 28 days of life)	7.04 [0.14, 362.25]	-	1 study		27	not evaluable	ROB	-
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions	1.99 [0.62, 6.38]	0%	2 studies	18	82	not evaluable	ROB	-
Late intrauterine deaths (> 22 weeks) / Stillbirths	3.72 [0.06, 246.38]	82%	2 studies	7	82	not evaluable	ROB	-
Elective/induced termination of pregnancy	0.99 [0.05, 19.69]	-	1 study	3	27	not evaluable	ROB	-
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