Interferon beta (IFN-beta) updated on 07-06-2020

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)0.97 [0.52, 1.81]0%6 studies5,034456serious ROB-
Major congenital malformations0.90 [0.44, 1.87]0%5 studies5,022387not evaluable ROB-
Congenital cataract--0 study-
Minor congenital malformations0.95 [0.10, 8.60]-1 study576not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.12 [0.63, 1.99]64%7 studies384703not evaluable ROB-
Low birth weight (< 2500g)5.76 [1.52, 21.84]-1 study1117not evaluable ROB11.00 [2.41; .]
Small for gestational age (weight)0.81 [0.27, 2.42]-1 study226not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean0.65 [0.13, 3.29]-1 study688not evaluable ROB-
Preeclampsia2.04 [0.54, 7.69]0%2 studies1156not evaluable ROB-
Assisted deliveries (forceps, vacuum, ...)2.45 [0.63, 9.53]-1 study3612not evaluable ROB-
Gestational diabetes0.51 [0.05, 5.02]0%2 studies256not evaluable ROB-
Maternal consequences (as a whole)0.55 [0.15, 2.07]-1 study2817not evaluable ROB-
Maternal infections2.72 [0.23, 31.79]-1 study317not evaluable ROB-
Placenta previa1.77 [0.07, 45.30]-1 study117not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Jaundice / Icterus1.46 [0.53, 4.01]0%3 studies19125not evaluable ROB-
Neonatal death (< 28 days of life)1.37 [0.14, 13.46]0%2 studies2268not evaluable ROB-
Neonatal disorders (as a whole)5.53 [1.72, 17.79]-1 study1717not evaluable ROB10.54 [2.83; .]
Neonatal medical care3.08 [0.12, 78.03]-1 study139not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Child/Infant infections (> 1 year)3.27 [0.94, 11.45]-1 study1139not evaluable ROB-
Child/Infant weight abnormalities (> 1 year)2.47 [0.15, 40.57]-1 study239not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Intrauterine deaths (as a whole or unspecified)1.16 [0.61, 2.22]23%4 studies95401not evaluable ROB-
Early intrauterine deaths (< 22 weeks) / Spontaneous abortions1.40 [0.82, 2.38]0%3 studies77361not evaluable ROB-
Elective/induced termination of pregnancy2.57 [0.28, 23.52]66%3 studies51641not evaluable ROB-
Late intrauterine deaths (> 22 weeks) / Stillbirths1.96 [0.36, 10.54]0%3 studies5361not evaluable ROB-
Ectopic pregnancy0.72 [0.03, 15.16]-1 study288not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
ASD (Autism spectrum disorder): Diagnosis7.56 [0.30, 189.77]-1 study139not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis/Risk7.56 [0.30, 189.77]-1 study139not evaluable ROB-
Cognitive developmental disorders/delay (> 6 years old)1.22 [0.11, 13.90]-1 study339not evaluable ROB-
Psychomotor developmental disorders/delay7.56 [0.30, 189.77]-1 study139not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis0.48 [0.02, 10.24]-1 study239not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk0.48 [0.02, 10.24]-1 study239not evaluable ROB-
Language disorders/delay0.32 [0.01, 8.22]-1 study139not evaluable ROB-
Learning disorders 0.81 [0.03, 20.31]-1 study139not evaluable ROB-

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