Interferon beta (IFN-β)

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
All congenital malformations (majors, minors, majors and minors, or unspecified)1.07 [0.53, 2.14]0%5 studies5,026402serious
Major congenital malformations1.02 [0.48, 2.15]0%4 studies5,019333not evaluable
Congenital cataract--0 study
Minor congenital malformations0.95 [0.10, 8.60]-1 study576not evaluable

Growth parameters and prematurity
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Preterm (< 37 weeks)1.12 [0.63, 1.99]64%7 studies384703not evaluable
Low birth weight (< 2500g)5.76 [1.52, 21.84]-1 study1117not evaluable
Small for gestational age (weight)0.81 [0.27, 2.42]-1 study226not evaluable

Maternal consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Caesarean0.65 [0.13, 3.29]-1 study688not evaluable
Preeclampsia1.33 [0.14, 12.67]-1 study517not evaluable
Assisted deliveries (forceps, vacuum, ...)2.45 [0.63, 9.53]-1 study3612not evaluable
Gestational diabete0.51 [0.05, 5.02]0%2 studies256not evaluable
Maternal consequences (as a whole)0.55 [0.15, 2.07]-1 study2817not evaluable
Maternal infections2.72 [0.23, 31.79]-1 study317not evaluable
Placenta previa1.77 [0.07, 45.30]-1 study117not evaluable

Neonatal disorders
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Jaundice1.46 [0.53, 4.01]0%3 studies19125not evaluable
Neonatal death1.37 [0.14, 13.46]0%2 studies2268not evaluable
Neonatal disorders (as a whole)5.53 [1.72, 17.79]-1 study1717not evaluable
Neonatal medical care3.08 [0.12, 78.03]-1 study139not evaluable

Long term consequences
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Children infections3.27 [0.94, 11.45]-1 study1139not evaluable

Intrauterine deaths
Adverse outcome VerdictOR 95%CI I2k No. casesNo. exposedpublication bias
Intrauterine deaths (as a whole)1.16 [0.61, 2.22]23%4 studies95401not evaluable
Early intrauterine death (< 22 weeks)1.40 [0.82, 2.38]0%3 studies77361not evaluable
Elective termination of pregnancy2.57 [0.28, 23.52]66%3 studies51641not evaluable
Late intrauterine deaths (> 22 weeks)1.96 [0.36, 10.54]0%3 studies5361not evaluable
Ectopic pregnancy0.72 [0.03, 15.16]-1 study288not evaluable

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