Adalimumab

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)2.51 [1.06, 5.97]31%5 studies62380not evaluable ROB4.46 [1.30; .]
Major congenital malformations2.30 [0.94, 5.64]37%4 studies62378not evaluable ROB-
Microcephaly / Small head circumference for gestational age1.46 [0.67, 3.17]-1 study39182not evaluable ROB-
Minor congenital malformations0.59 [0.31, 1.12]-1 study64173not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.17 [0.40, 3.41]0%3 studies42220not evaluable ROB-
Small for gestational age (weight)0.80 [0.40, 1.61]0%2 studies30208not evaluable ROB-
Macrosomia (> 4000g)21.00 [0.30, 1469.95]-1 study2not evaluable ROB-
Small for gestational age (length)1.05 [0.41, 2.68]-1 study19205not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean--0 study-
Maternal consequences (as a whole)9.00 [0.29, 275.58]-1 study15not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Neonatal infections0.96 [0.41, 2.23]0%2 studies66337not evaluable ROB-

Long term consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Cancer (all kind) in children or adults0.48 [0.01, 24.53]-1 study229not evaluable ROB-
Child/Infant head circumference abnormalities (> 1 year)2.10 [0.42, 10.45]-1 study11161not evaluable ROB-
Child/Infant weight abnormalities (> 1 year)1.17 [0.54, 2.52]-1 study41168not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)2.39 [0.78, 7.30]0%2 studies32260not evaluable ROB-
Elective/induced termination of pregnancy1.95 [0.15, 24.78]0%2 studies1260not evaluable ROB-
Late intrauterine deaths (> 22 weeks)0.47 [0.01, 23.62]-1 study257not evaluable ROB-
Intrauterine deaths (as a whole or unspecified)0.24 [0.01, 5.76]-1 study35not evaluable ROB-
Therapeutic terminations of pregnancy--0 study-

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