metaPreg - Lansoprazole during pregnancy

Lansoprazole

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.01 [0.90, 1.14]	0%	4 studies	114,826	7,475	not evaluable	ROB	-
Major congenital malformations	1.01 [0.90, 1.14]	0%	4 studies	114,826	7,475	not evaluable	ROB	-
Hypospadias	1.57 [0.70, 3.51]	13%	3 studies	3,342	3,309	not evaluable	ROB	-
Atrial septal defect	49.70 [1.92, 1288.78]	-	1 study	1	13	not evaluable	ROB	98.89 [3.24; .]
Cleft palate	1.00 [0.45, 2.25]	-	1 study	2,287	6,404	not evaluable	ROB	-
Congenital heart defects	0.96 [0.80, 1.16]	-	1 study	42,269	6,404	not evaluable	ROB	-
Congenital hydronephrosis	5.05 [0.20, 130.52]	-	1 study	1	13	not evaluable	ROB	-
Down syndrom / Trisomy 21	15.24 [0.29, 800.69]	-	1 study		13	not evaluable	ROB	-
Encephalocele	5.05 [0.20, 130.52]	-	1 study	1	13	not evaluable	ROB	-
Hydrocephaly	0.94 [0.23, 3.81]	-	1 study	786	6,404	not evaluable	ROB	-
Patent ductus arterious	15.24 [0.29, 800.69]	-	1 study		13	not evaluable	ROB	-
Ventricular septal defect	15.24 [0.29, 800.69]	-	1 study		13	not evaluable	ROB	-
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Low birth weight (< 2500g)	0.91 [0.83, 1.00]	-	1 study	104,538	8,678	not evaluable	ROB	1.43 [.; 1.04]
Preterm (< 37 weeks)	1.30 [0.57, 2.99]	-	1 study	93	48	not evaluable	ROB	-
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Infant asthma	1.70 [1.38, 2.09]	-	1 study		346	not evaluable	ROB	2.79 [2.10; .]
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.50 [0.62, 3.62]	-	1 study	64	62	not evaluable	ROB	-
Ectopic pregnancy	-	-	0 study					-
Elective/induced termination of pregnancy	3.96 [1.65, 9.51]	-	1 study	34	62	not evaluable	ROB	7.39 [2.69; .]
Late intrauterine deaths (> 22 weeks)	2.81 [0.13, 59.28]	-	1 study	2	62	not evaluable	ROB	-
Neuro-developmental disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neuro-developmental disorders (as a whole)	2.00 [0.87, 4.60]	-	1 study	138	25	not evaluable	ROB	-
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