Atenolol (versus unexposed) updated on 12-17-2024

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.78 [0.53, 5.93]-1 study4,05774not evaluable ROB-
Atrial septal defect0.90 [0.10, 7.95]-1 study1,1376not evaluable ROB-
Coarctation of aorta2.40 [0.16, 35.19]-1 study4066not evaluable ROB-
Congenital heart defects1.90 [0.63, 5.70]-1 study5,02116not evaluable ROB-
Ebstein's anomaly6.75 [0.37, 123.39]-1 study655not evaluable ROB-
Hypospadias0.86 [0.26, 2.83]-1 study2,13115not evaluable ROB-
Major congenital malformations1.78 [0.53, 5.93]-1 study4,05774not evaluable ROB-
Pulmonary valve stenosis4.20 [0.49, 36.01]-1 study5347not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Small for gestational age (weight)2.78 [2.23, 3.46]3%8 studies49,3451,038serious ROB5.00 [3.89; .]
Low birth weight (< 2500g)4.01 [3.33, 4.83]0%3 studies29,549746not evaluable ROB7.48 [6.11; .]
Preterm (< 37 weeks)2.70 [1.75, 4.17]0%2 studies7,894185not evaluable ROB4.85 [2.91; .]
Very low birth weight (< 1500g)4.21 [2.80, 6.34]-1 study3,465638not evaluable ROB7.89 [5.04; .]

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preeclampsia2.10 [0.64, 6.88]91%4 studies3,543863not evaluable ROB-
Caesarean2.48 [2.13, 2.88]0%3 studies104,581756not evaluable ROB4.39 [3.67; .]
Assisted deliveries (forceps, vacuum, ...)1.38 [0.89, 2.12]0%2 studies8,259678not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 1 min)2.02 [1.43, 2.84]21%3 studies22,618785not evaluable ROB3.45 [2.22; .]
Low Apgar score (< 7) (at 5 min)1.75 [0.53, 5.79]23%3 studies4,064785not evaluable ROB-
Neonatal hypoglycemia2.22 [0.80, 6.15]58%2 studies1191,161not evaluable ROB-
Low Apgar score (< 7) (at 10 min)2.06 [0.85, 4.97]-1 study1,435638not evaluable ROB-
Neonatal bradycardia1.16 [0.60, 2.26]-1 study431,121not evaluable ROB-
Very low Apgar score (< 5) (at 1 min)1.80 [0.08, 39.94]-1 study240not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Late intrauterine deaths (> 22 weeks)1.17 [0.23, 5.99]-1 study678not evaluable ROB-
Perinatal death0.33 [0.02, 5.28]-1 study1,379107not evaluable ROB-

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