Triptans

Table   Graphic     exposition period:

Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)0.99 [0.85, 1.15]0%4 studies57,1464,397not evaluable ROB-
Major congenital malformations0.97 [0.81, 1.17]0%4 studies39,0574,392not evaluable ROB-
Congenital heart defects1.32 [0.61, 2.88]57%2 studies13,7072,839not evaluable ROB-
Chromosomal abnormalities1.18 [0.44, 3.17]-1 study25325not evaluable ROB-
Limb defects1.36 [0.08, 22.06]-1 study18458not evaluable ROB-
Minor congenital malformations0.68 [0.06, 8.05]66%2 studies46387not evaluable ROB-
Nervous system anomalies1.20 [0.07, 19.50]-1 study20858not evaluable ROB-
Oro-facial clefts0.85 [0.05, 13.77]-1 study29458not evaluable ROB-
Digestive system anomalies0.69 [0.04, 11.18]-1 study36258not evaluable ROB-
Eye defects--0 study-
Genital anomalies0.80 [0.05, 12.89]-1 study31458not evaluable ROB-
Urinary malformations--0 study-
Abdominal wall defects--0 study-
Cardiac septal defects1.08 [0.67, 1.74]-1 study6,7922,777not evaluable ROB-
Ear, face and neck anomalies--0 study-
Gastroschisis0.80 [0.10, 6.38]-1 study5149not evaluable ROB-
Other anomalies/syndromes (non chromosomal)--0 study-
Respiratory system anomalies--0 study-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.03 [0.71, 1.48]73%7 studies4,4702,480not evaluable ROB-
Low birth weight (< 2500g)0.92 [0.71, 1.19]0%5 studies3,5782,692not evaluable ROB-
Small for gestational age (weight)1.08 [0.85, 1.38]0%2 studies2991,861not evaluable ROB-
Very low birth weight (< 1500g)0.73 [0.10, 5.40]-1 study658not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preeclampsia1.25 [0.73, 2.14]73%3 studies2752,183not evaluable ROB-
Abruptio placentae (retroplacental hematoma)2.80 [0.60, 13.08]-1 study9432not evaluable ROB-
Caesarean1.53 [0.74, 3.16]-1 study3880not evaluable ROB-
Gestational diabetes0.75 [0.33, 1.67]-1 study241,465not evaluable ROB-
Postpartum hemorrhage0.69 [0.44, 1.09]-1 study219185not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 5 min)1.52 [0.52, 4.41]-1 study14396not evaluable ROB-
Neonatal medical care0.77 [0.45, 1.33]-1 study136185not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Early intrauterine death (< 22 weeks)1.64 [0.94, 2.86]66%4 studies5,012686not evaluable ROB-
Elective/induced termination of pregnancy1.11 [0.42, 2.98]15%2 studies108508not evaluable ROB-
Late intrauterine deaths (> 22 weeks)0.65 [0.11, 3.86]0%2 studies7508not evaluable ROB-
Ectopic pregnancy1.21 [0.07, 19.73]-1 study276not evaluable ROB-
Intrauterine deaths (as a whole or unspecified)1.01 [0.56, 1.83]-1 studynot evaluable ROB-
Perinatal death1.23 [0.40, 3.80]-1 study658not evaluable ROB-

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