metaPreg - Clomiphene during pregnancy

Clomiphene

Table Graphic exposition period:

Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Congenital malformations
Neural Tube Defects	1.50 [1.00, 2.25]	0%	6 studies	2,953	2,488	not evaluable	ROB	-
All congenital malformations (majors, minors, majors and minors, or unspecified)	1.15 [0.98, 1.35]	0%	4 studies	28,973	2,286	not evaluable	ROB	-
Hypospadias	1.42 [0.93, 2.17]	21%	5 studies	5,360	2,181	not evaluable	ROB	-
Major congenital malformations	1.13 [0.95, 1.34]	0%	3 studies	28,953	2,286	not evaluable	ROB	-
Spina bifida	2.80 [0.20, 38.54]	89%	2 studies	706	138	not evaluable	ROB	-
Craniosynostosis	2.04 [1.34, 3.11]	0%	3 studies	901	2,001	not evaluable	ROB	3.51 [2.03; .]
Cleft lip with or without cleft palate	1.20 [0.75, 1.91]	2%	2 studies	3,072	219	not evaluable	ROB	-
Minor congenital malformations	4.44 [1.81, 10.91]	-	1 study	20	262	not evaluable	ROB	8.35 [3.01; .]
Ventricular septal defect	1.40 [0.81, 2.42]	5%	2 studies	1,380	1,986	not evaluable	ROB	-
Oesophageal atresia with or without tracheo-oesophageal fistula	2.41 [1.41, 4.11]	0%	2 studies	414	1,971	not evaluable	ROB	4.24 [2.17; .]
Cardiac septal defects	1.60 [1.13, 2.26]	-	1 study	3,320	168	not evaluable	ROB	2.58 [1.52; .]
Coarctation of aorta	1.80 [1.09, 2.97]	-	1 study	603	114	not evaluable	ROB	3.00 [1.40; .]
Omphalocele	2.20 [1.09, 4.45]	-	1 study	254	103	not evaluable	ROB	3.82 [1.40; .]
22 non statistically significant endpoints reported in only one study
Growth parameters and prematurity
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Preterm (< 37 weeks)	1.28 [0.83, 1.96]	52%	2 studies	107	1,598	not evaluable	ROB	-
Low birth weight (< 2500g)	1.43 [1.08, 1.91]	0%	2 studies	90	1,593	not evaluable	ROB	2.22 [1.37; .]
Small for gestational age (weight)	1.39 [1.05, 1.83]	12%	2 studies	5,398	1,659	not evaluable	ROB	2.12 [1.30; .]
1 non statistically significant endpoints reported in only one study
Maternal consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Neonatal disorders
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Long term consequences
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
1 non statistically significant endpoints reported in only one study
Intrauterine deaths
Adverse outcome	OR 95%CI	I2	k	No. cases	No. exposed	publication bias	ROB	E-value
Early intrauterine death (< 22 weeks)	1.82 [1.16, 2.85]	-	1 study	99	309	not evaluable	ROB	3.04 [1.60; .]
4 non statistically significant endpoints reported in only one study