Ondansetron

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Congenital malformations
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
All congenital malformations (majors, minors, majors and minors, or unspecified)1.04 [0.96, 1.12]43%8 studies167,592116,161not evaluable ROB-
Cleft lip with or without cleft palate1.01 [0.84, 1.21]0%6 studies3,75791,970not evaluable ROB-
Congenital heart defects1.13 [0.96, 1.33]66%6 studies59,616116,155not evaluable ROB-
Major congenital malformations1.02 [0.99, 1.05]0%7 studies150,947115,320not evaluable ROB-
Ventricular septal defect1.15 [1.01, 1.32]28%6 studies17,76595,806not evaluable ROB1.57 [1.10; .]
Cleft palate1.17 [0.72, 1.90]67%5 studies2,94591,009not evaluable ROB-
Oro-facial clefts1.20 [1.02, 1.40]0%4 studies3,506113,549not evaluable ROB1.68 [1.17; .]
Atrial septal defect1.09 [0.79, 1.50]87%4 studies4,51090,971not evaluable ROB-
Atrioventricular septal defect1.38 [0.65, 2.93]73%4 studies6,19090,765not evaluable ROB-
Club foot / Talipes equinovarus1.13 [0.85, 1.50]0%4 studies9852,710not evaluable ROB-
Hypospadias0.97 [0.71, 1.33]0%4 studies2,6101,729not evaluable ROB-
Limb defects1.03 [0.93, 1.13]0%3 studies7,82490,061not evaluable ROB-
Urinary malformations1.23 [1.03, 1.46]0%4 studies8,86591,075not evaluable ROB1.75 [1.21; .]
Ano-rectal atresia and stenosis0.54 [0.21, 1.38]0%2 studies1151,613not evaluable ROB-
Atresia or stenosis of other parts of small intestine1.01 [0.57, 1.78]0%2 studies1561,620not evaluable ROB-
Coarctation of aorta0.70 [0.41, 1.19]0%2 studies2011,619not evaluable ROB-
Craniosynostosis1.13 [0.95, 1.35]0%3 studies12,7652,512not evaluable ROB-
Diaphragmatic hernia1.70 [1.17, 2.48]0%3 studies8752,394not evaluable ROB2.80 [1.62; .]
Gastroschisis0.99 [0.58, 1.70]0%2 studies1961,624not evaluable ROB-
Hypoplastic left heart (HLH/HLHS)1.49 [0.86, 2.57]0%2 studies4601,267not evaluable ROB-
Pulmonary valve stenosis0.84 [0.48, 1.49]0%2 studies2301,623not evaluable ROB-
Severe congenital heart defect0.76 [0.63, 0.93]0%2 studies1,88088,851not evaluable ROB1.94 [.; 1.35]
Single ventricle0.90 [0.34, 2.37]71%2 studies42488,706not evaluable ROB-
Total anomalous pulm venous return0.84 [0.55, 1.30]0%2 studies50288,705not evaluable ROB-
Abdominal wall defects0.98 [0.90, 1.07]0%2 studies8,81689,679not evaluable ROB-
Bilateral renal agenesis including Potter syndrome1.85 [1.13, 3.02]0%2 studies1611,630not evaluable ROB3.10 [1.51; .]
Cardiac septal defects1.57 [1.17, 2.12]43%2 studies39,4752,528not evaluable ROB2.52 [1.61; .]
Congenital cataract0.94 [0.46, 1.91]0%2 studies2111,494not evaluable ROB-
Digestive system anomalies0.93 [0.85, 1.02]0%2 studies9,59889,700not evaluable ROB-
Eye defects0.95 [0.69, 1.30]0%2 studies77289,700not evaluable ROB-
Genital anomalies1.06 [0.97, 1.17]0%2 studies7,10089,679not evaluable ROB-
Limb reduction defects (LRD)1.01 [0.39, 2.58]0%2 studies5632,115not evaluable ROB-
Nervous system anomalies0.94 [0.81, 1.09]0%2 studies3,49689,679not evaluable ROB-
Oesophageal atresia with or without tracheo-oesophageal fistula0.71 [0.40, 1.28]0%2 studies3641,496not evaluable ROB-
Patent ductus arterious0.90 [0.73, 1.11]-1 study1,67588,446not evaluable ROB-
Respiratory system anomalies1.13 [1.01, 1.27]0%2 studies3,95189,679not evaluable ROB1.52 [1.08; .]
Spina bifida1.40 [0.79, 2.47]-1 study150390not evaluable ROB-
Transposition of the great vessels0.80 [0.40, 1.60]-1 study136383not evaluable ROB-
Anophthalmos/micropthalmos0.90 [0.31, 2.65]-1 study132257not evaluable ROB-
Anotia1.10 [0.59, 2.06]-1 study354263not evaluable ROB-
Aortic valve atresia/stenosis0.50 [0.20, 1.22]-1 study272260not evaluable ROB-
Atresia of bile ducts1.30 [0.51, 3.29]-1 study101258not evaluable ROB-
Bladder exstrophy and/or epispadia1.33 [0.05, 32.76]-1 study11,233not evaluable ROB-
Choanal atresia1.33 [0.05, 32.76]-1 study11,233not evaluable ROB-
Congenital constriction bands/amniotic band1.30 [0.51, 3.29]-1 study155258not evaluable ROB-
Congenital glaucoma4.00 [0.25, 64.04]-1 study21,233not evaluable ROB-
Congenital hydronephrosis0.80 [0.17, 3.65]-1 study121,233not evaluable ROB-
Congenital skin disorders0.57 [0.03, 11.07]-1 study31,233not evaluable ROB-
Ear malformations1.67 [1.17, 2.38]-1 study45088,446not evaluable ROB2.73 [1.62; .]
Ear, face and neck anomalies4.00 [0.25, 64.04]-1 study21,233not evaluable ROB-
Ebstein's anomaly1.10 [0.39, 3.11]-1 study108257not evaluable ROB-
Hirschsprung's disease1.20 [0.60, 2.40]-1 study110385not evaluable ROB-
Hydrocephaly1.40 [0.76, 2.57]-1 study254264not evaluable ROB-
Intestinal malrotation1.10 [0.57, 2.11]-1 study125385not evaluable ROB-
Microcephaly / Small head circumference for gestational age0.99 [0.18, 5.53]-1 study57428not evaluable ROB-
Multicystic renal dysplasia1.40 [0.83, 2.37]-1 study176394not evaluable ROB-
Neural Tube Defects0.60 [0.21, 1.70]-1 study71148not evaluable ROB-
Omphalocele1.10 [0.47, 2.56]-1 study187269not evaluable ROB-
Polydactyly0.36 [0.02, 6.58]-1 study51,233not evaluable ROB-
Pulmonary artery atresia1.33 [0.05, 32.76]-1 study11,233not evaluable ROB-
Pulmonary artery stenosis1.33 [0.05, 32.76]-1 study11,233not evaluable ROB-
Pulmonary valve atresia0.70 [0.23, 2.10]-1 study144257not evaluable ROB-
Situs inversus0.70 [0.27, 1.81]-1 study185257not evaluable ROB-
Syndactyly2.67 [0.45, 15.99]-1 study51,233not evaluable ROB-
Tetralogy of Fallot0.90 [0.57, 1.42]-1 study616274not evaluable ROB-

Growth parameters and prematurity
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Preterm (< 37 weeks)1.28 [0.76, 2.15]79%4 studies8,5763,213not evaluable ROB-
Low birth weight (< 2500g)1.04 [0.61, 1.77]50%3 studies7,4512,147not evaluable ROB-
Small for gestational age (weight)0.96 [0.69, 1.35]67%2 studies50,6642,047not evaluable ROB-

Maternal consequences
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Caesarean1.63 [1.28, 2.07]0%2 studies31,113339not evaluable ROB2.64 [1.87; .]
Preeclampsia1.54 [0.93, 2.56]0%2 studies4,362351not evaluable ROB-
Postpartum hemorrhage1.20 [0.71, 2.03]-1 study8,862251not evaluable ROB-

Neonatal disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Low Apgar score (< 7) (at 5 min)1.89 [0.62, 5.75]0%2 studies56735not evaluable ROB-
Neonatal medical care1.21 [0.94, 1.55]0%2 studies42,510351not evaluable ROB-
Persistent pulmonary hypertension--0 study-
Low Apgar score (< 7) (at 1 min)0.47 [0.04, 5.45]-1 study335not evaluable ROB-
Neonatal hypotension1.52 [0.06, 37.69]-1 study1143not evaluable ROB-
Neonatal tachypnea1.27 [0.24, 6.70]-1 study7143not evaluable ROB-

Intrauterine deaths
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
Late intrauterine deaths (> 22 weeks)1.11 [0.60, 2.05]0%4 studies6793,424not evaluable ROB-
Early intrauterine death (< 22 weeks)0.40 [0.32, 0.50]0%3 studies6423,095not evaluable ROB4.40 [.; 3.38]
Ectopic pregnancy1.82 [0.37, 8.83]-1 study91,070not evaluable ROB-
Elective/induced termination of pregnancy1.10 [0.71, 1.70]-1 study861,070not evaluable ROB-
Therapeutic terminations of pregnancy5.06 [0.24, 106.12]-1 study2176not evaluable ROB-
Intrauterine deaths (as a whole or unspecified)0.28 [0.01, 6.96]-1 study1100not evaluable ROB-

Neuro-developmental disorders
Adverse outcome OR 95%CII2k No. casesNo. exposedpublication biasROBE-value
ADHD (Attention deficit hyperactivity disorder): Diagnosis1.36 [0.95, 1.94]-1 study2,243163not evaluable ROB-
ADHD (Attention deficit hyperactivity disorder): Diagnosis/Risk1.36 [0.95, 1.94]-1 study2,243163not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis1.39 [0.97, 2.00]-1 study1,377173not evaluable ROB-
ASD (Autism spectrum disorder): Diagnosis/Risk1.39 [0.97, 2.00]-1 study1,377173not evaluable ROB-
Neuro-developmental disorders (as a whole)1.34 [0.82, 2.17]-1 study138213not evaluable ROB-

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